✦ LIBER ✦

Inhibition of tumour promoter-induced Epstein– Barr virus activation by diospyrin, a plant-derived antitumour compound, and its synthetic derivatives

✍ Scribed by A. W. Norhanom; Banasri Hazra

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 86 KB
Volume: 11
Category: Article
ISSN: 0951-418X
DOI: 10.1002/(sici)1099-1573(199712)11:8<588::aid-ptr152>3.0.co;2-8

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✦ Synopsis

Inhibition of tumour promotion by diospyrin, a plant-derived bioactive bisnaphthoquinonoid compound, and its two derivatives was examined by an in vitro assay utilizing the activation of Epstein-Barr virus (EBV) early antigen (EA) expression in EBV-genome-carrying human lymphoblastoid cells. Synthetic modifications of diospyrin resulted in positive improvement of its activity against tumour promotion by inhibiting EBV EA expression in Raji cells induced by 12-o-tetradecanoylphorbol-13-acetate (TPA).