Multiple mechanisms for cytotoxicity ind
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M. C. Miller III; C. N. Stineman; J. R. Vance; D. X. West; I. H. Hall
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Article
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1999
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John Wiley and Sons
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English
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The purpose of this study was to evaluate the mechanism by which 2-acetylpyrazine-4 N-substituted thiosemicarbazone copper II complexes mediate their cytotoxicity. These compounds were shown to be cytotoxic to a variety of human and rodent tumors in cell culture and are potent cytocidal agents as de