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Inhibition of tumor cell growth by antibodies induced after vaccination with peptides derived from the extracellular domain of Her-2/neu

Book ID
117659801
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
313 KB
Volume
38
Category
Article
ISSN
0959-8049

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Inhibition of tumor cell growth by antib
Inhibition of tumor cell growth by antibodies induced after vaccination with peptides derived from the extracellular domain of Her-2/neu
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## Abstract The anti Her‐2/neu monoclonal antibody Trastuzumab has strong inhibiting effects on tumor growth __in vitro__ and __in vivo__ and is therefore used for immunotherapy in breast cancer patients. Due to necessity of frequent applications, however, cost intensiveness of Trastuzumab treatmen

Antibody-induced growth inhibition is me
Antibody-induced growth inhibition is mediated through immunochemically and functionally distinct epitopes on the extracellular domain of the c-erbb-2 (her-2/neu) gene product p185
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## Abstract Over‐expression of the c‐__erb__B‐2 (HER‐2/__neu__) gene product p185 occurs in 30% of breast and ovarian cancers. The p185 protein might serve as a target for serotherapy in that antibodies against different epitopes on the extracellular domain of p185 can inhibit growth of tumor cells