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Inhibition of Trypanosoma cruzi trypanothione reductase by crystal violet

✍ Scribed by Silvia N.J. Moreno; Eva G.S. Carnieri; Roberto Docampo


Book ID
113261385
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
592 KB
Volume
67
Category
Article
ISSN
0166-6851

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The three-dimensional structure of the complex between Trypanosoma cruzi trypanothione reductase (TR) (EC 1.6.4.8) and the antiparasitic drug mepacrine (quinacrine) has been solved at 2.9 A resolution. Mepacrine is a competitive inhibitor of TR but does not affect human glutathione reductase (GR), a