The majority of malignant primary brain tumors are gliomas, derived from glial cells. Grade IV gliomas, Glioblastoma multiforme, are extremely invasive and the clinical prognosis for patients is dismal. Gliomas utilize a number of proteins and pathways to infiltrate the brain parenchyma including io
Inhibition of transient receptor potential canonical channels impairs cytokinesis in human malignant gliomas
β Scribed by V. C. Bomben; H. W. Sontheimer
- Book ID
- 108677811
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 635 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0960-7722
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## Abstract Members of the mammalian transient receptor potential (TRP) family form cationβpermeable channels at the plasma membrane implicated in capacitative calcium influx after activation by either secondβmessengerβmediated pathways or store depletion, or both. This study shows that with the us