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Inhibition of Transforming Growth Factor β Signaling Promotes Epiblast Formation in Mouse Embryos

✍ Scribed by Ghimire, Sabitri; Heindryckx, Björn; Van der Jeught, Margot; Neupane, Jitesh; O'Leary, Thomas; Lierman, Sylvie; De Vos, Winnok H.; Chuva de Sousa Lopes, Susana; Deroo, Tom; De Sutter, Petra

Book ID
127009694
Publisher
Mary Ann Liebert
Year
2015
Tongue
English
Weight
645 KB
Volume
24
Category
Article
ISSN
1547-3287

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Alterations in the transforming growth factor-beta (TGF-beta) pathway are implicated in the pathogenesis of colorectal cancer. We hypothesize that alterations in the TGF-beta pathway contribute to differential sensitivity of mice to the colon carcinogen azoxymethane (AOM). A/J (sensitive) and AKR/J