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Inhibition of transforming activity of the ret/ptc1 oncoprotein by a 2-indolinone derivative

โœ Scribed by Cinzia Lanzi; Giuliana Cassinelli; Tiziana Pensa; Marco Cassinis; Romolo A. Gambetta; Maria G. Borrello; Ernesto Menta; Marco A. Pierotti; Franco Zunino


Book ID
101234837
Publisher
John Wiley and Sons
Year
2000
Tongue
French
Weight
228 KB
Volume
85
Category
Article
ISSN
0020-7136

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The observation that mitogen-activated protein (MAP) kinases ERK1 and ERK2 are constitutively activated in a number of oncogene-transformed cell lines has led to the hypothesis that prolonged activation of these enzymes is required for the transformation process. To investigate this question, we hav