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Inhibition of thyroid hormone action by a non-hormone binding c-erbA protein generated by alternative mRNA splicing

✍ Scribed by Koenig, Ronald J.; Lazar, Mitchell A.; Hodin, Richard A.; Brent, Gregory A.; Larsen, P. Reed; Chin, William W.; Moore, David D.


Book ID
109757962
Publisher
Nature Publishing Group
Year
1989
Tongue
English
Weight
358 KB
Volume
337
Category
Article
ISSN
0028-0836

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Butyrate produced a biphasic modulation of the thyroid hormone receptor in neuroblastoma N2A cells increasing receptor number by 20-35 % at concentrations 0.25-0.75 mM and decreasing receptor levels by 3045% at 2 4 mM. The half-life of the receptor, as assessed by its disappearance after incubation