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Inhibition of the Wnt-β-catenin and Notch signaling pathways sensitizes osteosarcoma cells to chemotherapy

✍ Scribed by Ma, Yimin; Ren, Yongxin; Han, Ethan Q.; Li, Huiwu; Chen, Di; Jacobs, Joshua J.; Gitelis, Steven; O’Keefe, Regis J.; Konttinen, Yrjö T.; Yin, Guoyong; Li, Tian-Fang


Book ID
123205726
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
586 KB
Volume
431
Category
Article
ISSN
0006-291X

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## Abstract Notch and Wnt/β‐catenin signaling both play essential roles and interact closely in cardiomyocyte differentiation but the mechanism of interaction is largely unknown. Here we show that activation of Notch signaling in undifferentiated P19CL6 cells promoted cardiac differentiation, indic