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Inhibition of the soluble 5-lipoxygenase of the rat basophilic leukemic (RBL-1) cells by 5-lipoxygenase products and 15-hete

โœ Scribed by R.J. Soberman; R.A. Lewis; E.J. Corey; K.F. Austen

Book ID
119049980
Publisher
Elsevier Science
Year
1984
Tongue
English
Weight
54 KB
Volume
27
Category
Article
ISSN
0090-6980

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โœ L. Iversen; K. Fogh; K. Kragballe ๐Ÿ“‚ Article ๐Ÿ“… 1992 ๐Ÿ› Springer-Verlag ๐ŸŒ English โš– 478 KB

The purpose of the present study was to determine the effect of the n-6 fatty acid, dihomogammalinolenic acid (DGLA, 20 : 3, n-6) on arachidonic acid (AA) (C20:4) metabolism by human peripheral mononuclear leukocytes (HPML). After incubation of HPML with A23187 (5 ~tM) and DGLA, the cyclooxygenase (