✦ LIBER ✦

Inhibition of the shake response in rats by adenosine and 2-chloroadenosine

✍ Scribed by S. Y. H. Tse; E. T. Wei

Publisher: Springer
Year: 1986
Tongue: English
Weight: 470 KB
Volume: 90
Category: Article
ISSN: 0033-3158
DOI: 10.1007/bf00179184

No coin nor oath required. For personal study only.

✦ Synopsis

Shaking movements, similar to those made by a dog when wet, were elicited in rats by a)immersion in ice-water, b) injections of icilin, a chemical that produces sensations of cold, and c) naloxone-precipitated morphine withdrawal. Adenosine and 2-chloroadenosine produced dose-dependent inhibition of shaking to ice-water and icilin. The 2-chloroadenosine effect was mediated centrally because the ICV dose required to produce inhibition was not effective when given IP. Caffeine antagonized the inhibitory effects of adenosine and 2-chloroadenosine. 2-Chloroadenosine suppressed morphine-abstinence shaking as well as the body weight loss that normally accompanies withdrawal.

📜 SIMILAR VOLUMES

Pharmacology and toxicology of the A2A-a

Pharmacology and toxicology of the A2A-adenosine receptor agonist 2- [(cyclohexylmethylene)hydrazino]adenosine (MRE-0470) in the rat

✍ Pauline L. Martin; R.J. Barrett; A. Sykes; D.A. Droppleman; K.F. Wright; D. Moss 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 207 KB 👁 2 views

## 2-[(cyclohexylmethylene)hydrazino]adenosine (MRE-0470 ) is an A 2A -adenosine receptor agonist that is a potent and selective coronary vasodilator. As part of a preclinical program, the pharmacology and toxicology of MRE-0470 have been studied in the rat. In isolated vas deferens, MRE-0470 act

Development of the acoustic startle resp

Development of the acoustic startle response in the rat: Ontogenetic changes in the magnitude of inhibition by prepulse stimulation

✍ T. Parisi; James R. Ison 📂 Article 📅 1979 🏛 John Wiley and Sons 🌐 English ⚖ 649 KB

Inhibition of cell proliferation in the

Inhibition of cell proliferation in the embryonic myocardium by A1 adenosine receptor activation

✍ Zhiyong Zhao; Scott A. Rivkees 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 477 KB 👁 1 views

Ca2+ responses to acetylcholine and aden

Ca2+ responses to acetylcholine and adenosine triphosphate in the otocyst of chick embryo

✍ Nakaoka, Yoshikazu ;Yamashita, Masayuki 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 909 KB

The action of acetylcholine and adenosine triphosphate (ATP) on cytoplasmic Ca2+ concentration ([Ca2+Ji) was studied in the otocyst epithelium of embryonic day 3 chicks with Ca2+-sensitive fluorescence measurements. Increases in [Ca2+li were evoked by the bath application of acetylcholine (1 pM or h

Gender difference in the pharmacokinetic

Gender difference in the pharmacokinetic interaction between oral warfarin and oxolamine in rats: inhibition of CYP2B1 by oxolamine in male rats

✍ Xuan Zhu; Dae Y. Lee; Wan G. Shin 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 144 KB 👁 3 views

The protective role of adenosine in indu

The protective role of adenosine in inducing nitric oxide synthesis in rat liver ischemia preconditioning is mediated by activation of adenosine A2 receptors

✍ Carmen Peralta; Georgina Hotter; Daniel Closa; Neus Prats; Carme Xaus; Emilio Ge 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 378 KB 👁 2 views