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Inhibition of the renin-angiotensin system downregulates tissue factor and vascular endothelial growth factor in human breast carcinoma cells

✍ Scribed by Emanuela Napoleone; Antonella Cutrone; Daniela Cugino; Concetta Amore; Angelomaria Di Santo; Licia Iacoviello; Giovanni de Gaetano; Maria Benedetta Donati; Roberto Lorenzet


Book ID
116914957
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
544 KB
Volume
129
Category
Article
ISSN
0049-3848

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## Abstract Vascular endothelial growth factor receptor 1 (VEGFR‐1) is present on endothelial cells and subsets of human tumor cells, raising the hypothesis that angiogenic factors may promote tumor growth both by inducing angiogenesis and directly signaling through activation of VEGFR‐1 on tumor c