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Inhibition of the proteasome activity, a novel mechanism associated with the tumor cell apoptosis-inducing ability of genistein

✍ Scribed by Aslamuzzaman Kazi; Kenyon G. Daniel; David M. Smith; Nagi B. Kumar; Q.Ping Dou

Book ID: 113993634
Publisher: Elsevier Science
Year: 2003
Tongue: English
Weight: 432 KB
Volume: 66
Category: Article
ISSN: 0006-2952
DOI: 10.1016/s0006-2952(03)00414-3

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The multicatalytic protease complex or proteasome is a fundamental nonlysosomal tool that the cell uses to process or degrade proteins at a fast rate through the ubiquitin and ATP-dependent proteolytic pathway. Examples of these important proteins include the tumor suppressor protein p53, various cy