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Inhibition of the production of proinflammatory cytokines and immunoglobulins by interleukin-4 in an ex vivo model of rheumatoid synovitis

✍ Scribed by Pierre Miossec; Jérǒme Briolay; Julie Dechanet; John Wijdenes; Hector Martinez-Valdez; Jacques Banchereau


Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
930 KB
Volume
35
Category
Article
ISSN
0004-3591

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## Objective: To investigate the effects of the antiinflammatory cytokines interleukin-4 (il-4), il-10, and il-13 on tumor necrosis factor alpha (tnfalpha)-induced prostaglandin e2 (pge2) release in the cellular signaling cascade on human osteoarthritis (oa) synovial fibroblasts. ## Methods: Huma