Inhibition of the procoagulant activity of blood platelets by vinylsulfonyl derivatives of pyrrolidine-2-carboxylic acid
β Scribed by K. V. Kudryavtsev; N. A. Podoplelova; A. A. Novikova; M. A. Panteleev; D. V. Zabolotnev; N. S. Zefirov
- Book ID
- 106521950
- Publisher
- Springer
- Year
- 2011
- Tongue
- English
- Weight
- 283 KB
- Volume
- 60
- Category
- Article
- ISSN
- 1573-9171
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The title compounds were prepared from valine-derived N-acylated oxazolidin-2-ones, 1 Β± 3, 7, 9, by highly diastereoselective ( ! 90%) Mannich reaction ( 3 4 Β± 6; Scheme 1) or aldol addition ( 3 8 and 10; Scheme 2) of the corresponding Ti-or B-enolates as the key step. The superiority of the -5,5-di