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Inhibition of the PI3K Pathway Suppresses Hormonal Secretion and Limits Growth in Pheochromocytoma Cells

✍ Scribed by Joel T. Adler; Daniel G. Hottinger; Muthusamy Kunnimalaiyaan; Herbert Chen


Book ID
105980755
Publisher
Springer
Year
2009
Tongue
English
Weight
234 KB
Volume
33
Category
Article
ISSN
0364-2313

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Suppression of the PI3K subunit p85Ξ± del
✍ Susan M.R. Gurney; Peter Forster; Ursula Just; Ralf Schwanbeck πŸ“‚ Article πŸ“… 2011 πŸ› John Wiley and Sons 🌐 English βš– 360 KB

Phosphatidylinositol-3-kinases (PI3Ks) exert a variety of signaling functions in eukaryotes. We suppressed the PI3K regulatory subunit p85a using a small interfering RNA (Pik3r1 siRNA) and examined the effects on embryoid body (EB) development in hanging drop culture. We observed a 150% increase in