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Inhibition of the Na+/H+ exchanger reduces rat hepatic stellate cell activity and liver fibrosis: An in vitro and in vivo study

✍ Scribed by Antonio Benedetti; Antonio Di Sario; Alessandro Casini; Francesco Ridolfi; Emanuele Bendia; Paola Pigini; Cecilia Tonnini; Letizia D'Ambrosio; Giuseppe Feliciangeli; Giampiero Macarri; Gianluca Svegliati-Baroni


Book ID
119756115
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
832 KB
Volume
120
Category
Article
ISSN
0016-5085

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## Abstract ## Background/aims Transforming growth factor Ξ² (TGFΞ²1) is considered the key mediator in the process of liver fibrosis. The purpose of this investigation was to evaluate the activity of ribozymes against TGFΞ²1 in a cell‐free system and activated hepatic stellate cells (HSCs), and anti