✦ LIBER ✦
Inhibition of the induction of collagenase by interleukin-1 β in cultured rabbit synovial fibroblasts after treatment with the poly(ADP-ribose)-polymerase inhibitor 3-aminobenzamide
✍ Scribed by W. Ehrlich; H. Huser; H. Kröger
- Book ID
- 104713438
- Publisher
- Springer
- Year
- 1995
- Tongue
- English
- Weight
- 217 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0172-8172
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✦ Synopsis
3-Aminobenzamide is an inhibitor of poly-(ADP-ribosyl)ation. In concentrations from 3 to 10 mM it reduced the collagenase activity in culture supernatants of interleukin-1 beta-stimulated rabbit synovial fibroblasts. 3-Aminobenzoate, not an inhibiter of poly(ADP-ribosyl)ation, had no effect on collagenase activity at a concentration of 10 mM. We concluded that poly(ADP-ribosyl)ation plays a role in the induction of the expression of collagenase and that 3-aminobenzamide can inhibit this process.