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Inhibition of the H+/Peptide Cotransporter in the Human Intestinal Cell Line Caco-2 by Cyclic AMP

✍ Scribed by Ulrike Muller; Matthias Brandsch; Puttur D. Prasad; You-Jun Fei; Vadivel Ganapathy; Frederick H. Leibach

Book ID
115577889
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
64 KB
Volume
218
Category
Article
ISSN
0006-291X

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The transport of 10 amino acid ester prodrugs of levovirin (LVV) was investigated in the human intestinal Caco-2 cell line in order to overcome the poor oral bioavailability of LVV, an investigational drug for the treatment of hepatitis C infection. The prodrugs were designed to improve the permeabi