Inhibition of the growth of mammalian cells in culture by amino acids and the isolation and characterization ofL-phenylalanine-resistant mutants modifyingL-phenylalanine transport

Inhibition of growth of cells in culture

Inhibition of growth of cells in culture by L-phenylalanine as a model system for the analysis of phenylketonuria. I. Amino acid antagonism and the inhibition of protein synthesis

✍ L. Dillehay; R. Bass; E. Englesberg 📂 Article 📅 1980 🏛 John Wiley and Sons 🌐 English ⚖ 872 KB

## Abstract Phenylalanine in high concentrations inhibits the growth of mouse A9 cells. Protein synthesis is inhibited earlier and more severely than RNA or DNA synthesis. Phenylalanine inhibits the uptake and decreases the intracellular pool of several amino acids. Certain amino acids added in exc