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Inhibition of the expression of mitogen-activated protein kinase phosphatase-1 potentiates JNK-related apoptosis in renal cancer cells

✍ Scribed by R. Mizuno; M. Oya; A. Horiguchi; T. Shiomi; K. Marumo; Y. Okada; M. Murai

Book ID
118644872
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
206 KB
Volume
2
Category
Article
ISSN
1569-9056

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## Abstract ## Objective Mitogen‐activated protein kinases (MAPKs) are activated by proinflammatory stimuli. MAPK phosphatases (MKPs), in particular MKP‐1, have been identified as endogenous negative regulators of MAPK activation. Since MAPKs are known to be important in rheumatoid arthritis (RA)