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Inhibition of the double-stranded RNA-dependent protein kinase PKR by mammalian ribosomes

โœ Scribed by Daniel A Raine; Ian W Jeffrey; Michael J Clemens


Book ID
117109799
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
291 KB
Volume
436
Category
Article
ISSN
0014-5793

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Two major changes in RNA metabolism occured in macrophages expressing tumoricidal activity: a down regulation of total RNA synthesis and an imbalanced accumulation of ribosomal RNA precursors with double stranded secondary structure. The aim of this study was to investigate a possible role of endoge