Inhibition of the development of hepatocellular carcinomas by phenyl N-tert-butyl nitrone in rats fed with a choline-deficient, l-amino acid-defined diet
✍ Scribed by Dai Nakae; Fumiyuki Uematsu; Hideki Kishida; Osamu Kusuoka; Shin-ichi Katsuda; Midori Yoshida; Masakazu Takahashi; Akihiko Maekawa; Ayumi Denda; Yoichi Konishi; Yashige Kotake; Robert A Floyd
- Book ID
- 116332933
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 491 KB
- Volume
- 206
- Category
- Article
- ISSN
- 0304-3835
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## Abstract To elucidate whether the M6p/Igf2 receptor (M6p/Igf2r) gene might be involved in exogenous and endogenous liver carcinogenesis, we investigated its alteration in hepatocellular carcinomas (HCCs) induced by __N__‐nitrosodiethylamine (DEN) and by a choline‐deficient L‐amino acid‐defined (
## Abstract We investigated DNA methylation patterns of E‐cadherin and Connexin26 (Cx26) genes in rat hepatocellular carcinomas (HCCs) induced by a choline‐deficient L‐Amino Acid‐defined (CDAA) diet. Six‐wks‐old F344 male rats were continuously fed with a CDAA diet for 75 wks, and were then killed.