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Inhibition of the classical activation pathway of complement-mediated lysis by monoclonal antibodies to complement components C3c and C3d

โœ Scribed by R.E. Mushens; T. Bakacs

Book ID
114439378
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
417 KB
Volume
32
Category
Article
ISSN
0372-1248

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โœ M. Andersson; A. Hanson; G. Englund; B. Dahlbรคck ๐Ÿ“‚ Article ๐Ÿ“… 1991 ๐Ÿ› Springer ๐ŸŒ English โš– 537 KB

The effect of cadralazine and its active metabolite CGP 22639 on the covalent binding reaction of C4 and C3 has been studied. Trypsin-Sepharose was used to activate radio-labelled C3 and C4 and binding of the radio-labelled protein to the trypsin-Sepharose was measured. Cadralazine inhibited 50% of