The Bloom (BLM) and Werner's (WRN) syndrome proteins may regulate recombination and DNA repair. Using a novel polyclonal antibody to human BLM, we detected the 170-kda BLM antigen in wild-type but not Bloom syndrome cells. BLM was localized to punctate nuclear structures. The level of BLM but not WR
✦ LIBER ✦
Inhibition of the Bloom's and Werner's Syndrome Helicases by G-Quadruplex Interacting Ligands †
✍ Scribed by Li, Ji-Liang; Harrison, R. John; Reszka, Anthony P.; Brosh,, Robert M.; Bohr, Vilhelm A.; Neidle, Stephen; Hickson, Ian D.
- Book ID
- 121490847
- Publisher
- American Chemical Society
- Year
- 2001
- Tongue
- English
- Weight
- 326 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0006-2960
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