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Inhibition of the ATP-sensitive potassium channel from mouse pancreatic β-cells by surfactants

✍ Scribed by Paul A Smith; Peter Proks


Book ID
110003628
Publisher
Nature Publishing Group
Year
1998
Tongue
English
Weight
479 KB
Volume
124
Category
Article
ISSN
0007-1188

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ATP-inhibited potassium channels (K(ATP)) were studied in excised, inside-out patches from cultured adult mouse pancreatic beta-cells and HIT cells. In the absence of ATP, ADP opened K(ATP) channels at concentrations as low as 10 microM and as high as 500 microM, with maximal activation between 10 a