Effect of ethanol and high-fat feeding o
✍
Shelly C. Lu; Zong-Zhi Huang; Jin May Yang; Hidekazu Tsukamoto
📂
Article
📅
1999
🏛
John Wiley and Sons
🌐
English
⚖ 204 KB
Glutathione (GSH) is important in antioxidant defense. A major determinant of the rate of GSH synthesis is the activity of the rate-limiting enzyme, ␥-glutamylcysteine synthetase (GCS). A heavy (HS) and light subunit (LS) make up GCS; oxidative stress regulates both transcriptionally. Cis-acting ele