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Inhibition of tetramethylpyrazine on P-gp, MRP2, MRP3 and MRP5 in multidrug resistant human hepatocellular carcinoma cells

✍ Scribed by Xiang,


Book ID
120354344
Publisher
Spandidos Publications Ltd
Year
2009
Tongue
English
Weight
172 KB
Volume
23
Category
Article
ISSN
1021-335X

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Treatment of hepatocellular carcinoma (HCC) by chemotherapy is often impeded by the intrinsic multidrug resistance (MDR) of this frequent primary cancer of the liver. The MDR phenotype can be caused by ATP-dependent export of chemotherapeutic drugs across the plasma membrane being mediated by transp