Inhibition of telomerase activity in U937 human monocytic leukemia cells by Compound K, a ginseng saponin metabolite
β Scribed by Kyoung Ah Kang; Kyoung Hwa Lee; Sungwook Chae; Jeong Ki Kim; Jung Yeon Seo; Yong Ho Ham; Kee Ho Lee; Bum Joon Kim; Hee Sun Kim; Dong Hyun Kim; Jin Won Hyun
- Publisher
- The Korean Society for Biotechnology and Bioengineering
- Year
- 2006
- Tongue
- English
- Weight
- 390 KB
- Volume
- 11
- Category
- Article
- ISSN
- 1226-8372
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Human monocytic leukemia U937 cells undergo apoptosis when treated with antitumor drugs, such as etoposide, camptothecin and mitomycin C. The molecular mechanism of the drug-induced apoptosis is not well understood. In this study, we found that 2-deoxyglucose (2DG), an analog of D-glucose and an ind
## Abstract Arsenite has been reported to exert doseβdependent dual effects: triggering apoptosis at relatively high concentrations, whereas inducing partial differentiation at low concentrations in leukemia cells. However, the relevant molecular mechanisms of its action at low and nonapoptotic con