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Inhibition of surface induced coagulation by preadsorption of albumin-heparin conjugates

✍ Scribed by Hennink, W. E. ;Kim, S. W. ;Feijen, J.

Publisher
John Wiley and Sons
Year
1984
Tongue
English
Weight
942 KB
Volume
18
Category
Article
ISSN
0021-9304

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✦ Synopsis

Surface coatings of the albumin-heparin conjugates were developed to improve the blood compatibility of polymeric materials. Glass, PVC, Biomer and cellulose acetate were coated with albumin-heparin conjugate and its adsorption and desorption behavior on glass in particular was studied using 3H and 51Cr radiolabeled conjugates. Precoated materials showed a significant prolongation of the Lee-White clotting time as compared with noncoated ones. It was demonstrated that the prolonged clotting time for pretreated glass was due to surface bound conjugate. Prolonged recalcification times of plasma exposed to glass, Biomer, and PVC were obtained using albumin-heparin conjugate precoated surfaces. Albumin-heparin conjugates with high affinity for antithrombin I11 gave more prolonged clotting times as low affinity conjugates when used as coatings for glass. This indicates that the behaviour of heparin in preadsorbed conjugates resembles that of heparin in solution.

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