Inhibition of Streptococcus mutans 6715 glucosyltransferases by sucrose analogs modified at positions 6 and 6′

Synthesis of 4,6-dideoxysucrose, and inh

Synthesis of 4,6-dideoxysucrose, and inhibition studies of leuconostoc and streptococcus d-glucansucrases with deoxy and chloro derivatives of sucrose modified at carbon atoms 3, 4, and 6

✍ Aziz Tanriseven; John F. Robyt 📂 Article 📅 1989 🏛 Elsevier Science 🌐 English ⚖ 548 KB

Starting from sucrose, 2,3,1' ,3',4',6'-hexa-O-benzoyl-6-deoxy-6-iodosucrose\* (1) was synthesized. ## Reaction of 1 with sulfuryl chloride in pyridine gave 2,3,1 ',3',4',6'-hexa-O-benzoyl-4-chloro-4,6-dideoxy-6-iodogalactosucrose (2). Compound 2 was treated with tributyltin hydride in toluene i