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Inhibition of steroid sulfatase activity and cell proliferation in ZR-75-1 and BT-474 human breast cancer cells by KW-2581 in vitro and in vivo

✍ Scribed by Hiroyuki Ishida; Taisuke Nakata; Natsuko Sato; Pui-Kai Li; Takashi Kuwabara; Shiro Akinaga

Publisher: Springer US
Year: 2006
Tongue: English
Weight: 361 KB
Volume: 104
Category: Article
ISSN: 0167-6806
DOI: 10.1007/s10549-006-9404-8

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## Abstract ## BACKGROUND Antagonists of growth hormone‐releasing hormone (GH‐RH) can inhibit the proliferation of various tumors either indirectly through the suppression of the pituitary growth hormone/hepatic insulin‐like growth factor I (__IGF‐I__) axis and the lowering of serum __IGF‐I__ conc