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Inhibition of skin sclerosis by 15deoxy Δ12,14-prostaglandin J2 and retrovirally transfected prostaglandin D synthase in a mouse model of bleomycin-induced scleroderma

✍ Scribed by Shizuka Kohno; Hirahito Endo; Atsushi Hashimoto; Izumi Hayashi; Yusuke Murakami; Hidero Kitasato; Fumiaki Kojima; Shinichi Kawai; Hirobumi Kondo


Book ID
116313565
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
543 KB
Volume
60
Category
Article
ISSN
0753-3322

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Objective. The cyclooxygenase (COX) metabolite, 15-deoxy-⌬ 12,14 -prostaglandin J 2 (15d-PGJ 2 ), has been reported to inhibit the expression of a number of genes involved in the pathogenesis of arthritis. However, its effects on COX-2 remain controversial. We undertook this study to investigate the