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Inhibition of sigma-1 receptor reduces N-methyl-d-aspartate induced neuronal injury in methamphetamine-exposed and -naive hippocampi

โœ Scribed by Katherine J. Smith; Tracy R. Butler; Mark A. Prendergast


Book ID
116772426
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
241 KB
Volume
481
Category
Article
ISSN
0304-3940

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## Abstract The Nโ€methylโ€Dโ€aspartate receptor (NMDAR) is fundamental to normal and pathological functioning of neurons. The receptor subunits are Nโ€glycosylated proteins synthesized in the endoplasmic reticulum (ER) that fold, mature, and oligomerize as they transit through the secretory pathway. A