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Inhibition of S6K1 enhances glucose deprivation-induced cell death via downregulation of anti-apoptotic proteins in MCF-7 breast cancer cells

✍ Scribed by Choi, Ha-Na; Jin, Hyeon-Ok; Kim, Jae-Hee; Hong, Sung-Eun; Kim, Hyun-Ah; Kim, Eun-Kyu; Lee, Jin Kyung; Park, In-Chul; Noh, Woo Chul


Book ID
120599624
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
420 KB
Volume
432
Category
Article
ISSN
0006-291X

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## Abstract Insulin receptor substrate 1 (IRS‐1) is a major downstream signaling protein for insulin and insulin‐like growth factor I (IGF‐I) receptors, conveying signals to PI‐3K/Akt and ERK1/2 pathways. In breast cancer, IRS‐1 overexpression has been associated with tumor development, hormone‐ind