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Inhibition of RNAse A family enzymes prevents degradation and loss of silencing activity of siRNAs in serum

✍ Scribed by Jörg Haupenthal; Christina Baehr; Simone Kiermayer; Stefan Zeuzem; Albrecht Piiper


Book ID
113487836
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
473 KB
Volume
71
Category
Article
ISSN
0006-2952

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RNAse A-like enzymes in serum inhibit th
✍ Jörg Haupenthal; Christina Baehr; Stefan Zeuzem; Albrecht Piiper 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 French ⚖ 262 KB

## Abstract Down‐modulation of target molecules in tumor cells by small interfering (si) RNAs is a promising anti‐cancer strategy. A major challenge of this approach is the loss of silencing activity of the siRNAs __in vivo__. Our study aimed at investigating the influence of the serum compartment