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Inhibition of receptor-mediated uptake of a lysosomal enzyme into fibroblasts by chloroquine, procaine and ammonia

✍ Scribed by Gloria N. Sando; Pauline Titus-Dillon; Clara W. Hall; Elizabeth F. Neufeld

Book ID: 118877498
Publisher: Elsevier Science
Year: 1979
Tongue: English
Weight: 485 KB
Volume: 119
Category: Article
ISSN: 0014-4827
DOI: 10.1016/0014-4827(79)90364-1

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## Abstract The role of the matricellular protein SPARC (secreted protein, acidic and rich in cysteine) in modulation of vascular cell proliferation is believed to be mediated, in part, by its ability to regulate the activity of certain growth factors through direct binding. In this study, we demon