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Inhibition of rat liver microsomal bilirubin UDP-glucuronosyltransferase by ursodeoxycholic acid

✍ Scribed by Enrique J. Sánchez Pozzi; Marcelo G. Luquita; Viviana A. Catania; Emilio A. Rodríguez Garay; Aldo D. Mottino

Book ID
118347173
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
670 KB
Volume
55
Category
Article
ISSN
0024-3205

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Mechanism of inhibition of rat liver bil
Mechanism of inhibition of rat liver bilirubin UDP-glucuronosyltransferase by triphenylalkyl derivatives
✍ Mourad Said; Eric Battaglia; Abdelaziz Elass; Virginie Cano; Jean-Claude Ziegler 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 126 KB

A series of potent and competitive inhibitors of UDP-glucuronosyltransferase derived from 7,7,7-triphenylheptanoic acid has been synthesized in order to probe the active site of the isozyme involved in the glucuronidation of the endogenous toxic compound, bilirubin IX␣. Like triphenylalkylcarboxylic