Rapid reversal of angiotensin converting
Rapid reversal of angiotensin converting enzyme inhibition by lisinopril in the perfused rabbit lung
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S. Rimar; C.N. Gillis
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Article
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1992
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Elsevier
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English
β 502 KB
Lisinopril is a potent competitive inhibitor of purified rabbit lung ACE (dissociation t1/2 = 105 min). To examine reversibility of binding and ACE functional activity in situ, the single-pass extraction (E) of an 125I-lisinopril analogue (351A) and the hydrolysis of an ACE substrate, benz-phe-ala-p