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Inhibition of rabbit liver microsomal oxidative metabolism and substrate binding by tamoxifen and the geometric isomers of clomiphene

✍ Scribed by Peter C. Ruenitz; Mo M. Toledo

Book ID
115775431
Publisher
Elsevier Science
Year
1980
Tongue
English
Weight
480 KB
Volume
29
Category
Article
ISSN
0006-2952

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## SYNOPSIS The triphenylethylene antiestrogen trans-tamoxifen is an effective antitumor agent used in the treatment of human breast cancer. While the antiestrogenic activity of trans- tamoxifen clearly plays an important role in its tumoricidal action, some of the biological effects of trans-tamo