Inhibition of Pseudomonas burn wound infection by mafenide dry foam

✍ Scribed by Patrick N. Catania; James C. King

• Publisher: John Wiley and Sons
• Year: 1975
• Tongue: English
• Weight: 234 KB
• Volume: 64
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600640235

✦ Synopsis

The results of an in uiuo evaluation of 8.5% mafenide dry foam are described. Using burned guinea pigs infected with Pseudomonas aeruginosa, mafenide was applied every 12 hr as the dry foam or as the commercially available ointment. After 156 hr of therapy with the medicated dosage forms, the previously infected areas did not demonstrate the presence of Pseudomonas. However, all nonmedicated, infected controls produced positive cultures. Both medicated dosage forms demonstrated equivalent efficacy in the inhibition of Pseudomonas on burn wounds.

Keyphrases 0 Mafenide-dry foam formulation, inhibition of Pseudomonas burn wound infection 0 Burns-inhibition of Pseudomonas burn wound infection by mafenide dry foam 0 Pseudomonas infections in burns-inhibition by mafenide dry foam Earlier (l), the formulation and in uitro evaluation of medicated dry foams were reported. The dry foam was described as a light, flexible, aerated film, with ' Sulfamylon Cream, Winthrop Laboratories, Inc.,