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Inhibition of protein tyrosine phosphatase activity mediates epidermal growth factor receptor signaling in human airway epithelial cells exposed to Zn2+

✍ Scribed by T.L. Tal; L.M. Graves; R. Silbajoris; P.A. Bromberg; W. Wu; J.M. Samet


Book ID
113923834
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
433 KB
Volume
214
Category
Article
ISSN
0041-008X

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Compound 5 (Cpd 5), a synthetic K vitamin analogue, or 2-(2-mercaptoethanol)-3-methyl-1,4-naphthoquinone, is a potent inhibitor of epidermal growth factor (EGF)-induced rat hepatocyte DNA synthesis and induces EGF receptor (EGFR) tyrosine phosphorylation. To understand the cellular responses to Cpd