Inhibition of protein kinase CK2 expression and activity blocks tumor cell growth
β Scribed by Dan Zhu; Jennifer Hensel; Robert Hilgraf; Mahan Abbasian; Owen Pornillos; Gordafaried Deyanat-Yazdi; Xuequn Helen Hua; Sarah Cox
- Book ID
- 106458968
- Publisher
- Springer
- Year
- 2009
- Tongue
- English
- Weight
- 581 KB
- Volume
- 333
- Category
- Article
- ISSN
- 0300-8177
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Protein kinase CK2, formerly known as casein kinase II, is a ubiquitous protein serine/threonine kinase. The enzyme exists in tetrameric complexes composed of two catalytic (CK2a and/or CK2a8) subunits and two subunits (CK2b) that appear to have a role in modulating the activity of the catalytic sub
## Abstract Increasing evidence points to a link between histone deacetylases (HDACs) and tumorigenesis. Although several HDAC inhibitors have been tested in clinical trials for cancer therapies, the mechanisms of HDAC activation in tumors remain unknown. In this study, we investigated the pathway