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Inhibition of protein kinase CK2 expression and activity blocks tumor cell growth

✍ Scribed by Dan Zhu; Jennifer Hensel; Robert Hilgraf; Mahan Abbasian; Owen Pornillos; Gordafaried Deyanat-Yazdi; Xuequn Helen Hua; Sarah Cox


Book ID
106458968
Publisher
Springer
Year
2009
Tongue
English
Weight
581 KB
Volume
333
Category
Article
ISSN
0300-8177

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## Abstract Increasing evidence points to a link between histone deacetylases (HDACs) and tumorigenesis. Although several HDAC inhibitors have been tested in clinical trials for cancer therapies, the mechanisms of HDAC activation in tumors remain unknown. In this study, we investigated the pathway