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Inhibition of protein kinase C-mediated contraction by Rho kinase inhibitor fasudil in rabbit aorta

✍ Scribed by Erika Shimomura; Mitsuya Shiraishi; Takahiro Iwanaga; Minoru Seto; Yasuharu Sasaki; Masahiro Ikeda; Katsuaki Ito


Publisher
Springer-Verlag
Year
2004
Tongue
English
Weight
324 KB
Volume
370
Category
Article
ISSN
0028-1298

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The activation of intracellular contractile proteins induces vascular contraction mediated through signal transduction mechanisms. Protein kinase C (PKC) is involved in this signal transduction. The purpose of the present study was designed to investigate the role of PKC on EtOH-, KCl-and phorbol 12