Inhibition of protein kinase C by sphingosine correlates with the presence of positive charge
✍ Scribed by Remo Bottega; Richard M. Epand; Eric H. Ball
- Book ID
- 115761933
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- English
- Weight
- 406 KB
- Volume
- 164
- Category
- Article
- ISSN
- 0006-291X
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract In certain cell systems, including neonatal vascular smooth muscle (VSM) cells, phorbol esters are growth inhibitory. Here we show that 1, 2‐dioctanoyl‐snglycerol (DiC8), when added 2 h after α‐thrombin, reverses by 95% the induction of DNA synthesis in VSM cells by α‐thrombin. Sphingos
Signal transduction pathways controlling tumor cell locomotion are not yet well understood. We have studied the role of protein kinase C (PKC)-dependent protein phosphorylation associated with changes in cell shape and locomotor activity of Walker carcinosarcoma cells in culture. We show that the in