The pure antiestrogen ICI 182,780 inhibits insulin-like growth factor (IGF)-dependent proliferation in hormoneresponsive breast cancer cells. However, the interactions of ICI 182,780 with IGF-I receptor (IGF-IR) intracellular signaling have not been characterized. Here, we studied the effects of ICI
β¦ LIBER β¦
Inhibition of progesterone-induced VEGF production in human breast cancer cells by the pure antiestrogen ICI 182,780
β Scribed by Salman M. Hyder; George M. Stancel
- Book ID
- 117467315
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 116 KB
- Volume
- 181
- Category
- Article
- ISSN
- 0304-3835
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To elucidate the mechanisms responsible for the development of anti-estrogen resistance, we have cloned and established 3 stable ICI-182,780-resistant sub-lines, MCF-7/182 R -1, MCF-7/182 R -6 and MCF-7/182 R -7 from the estrogen-receptor(ER)-positive and estrogen-responsive human breastcancer MCF-7