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Inhibition of pro-inflammatory cytokine production by the dual p38/JNK2 inhibitor BIRB796 correlates with the inhibition of p38 signaling

✍ Scribed by Lore M. Gruenbaum; Racheline Schwartz; Joseph R. Woska Jr.; Rodney P. DeLeon; Gregory W. Peet; Thomas C. Warren; Alison Capolino; Lisa Mara; Maurice M. Morelock; Anthony Shrutkowski; Jessi Wildeson Jones; Christopher A. Pargellis


Book ID
113488680
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
757 KB
Volume
77
Category
Article
ISSN
0006-2952

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X-ray crystal structure of JNK2 complexe
✍ Andreas Kuglstatter; Manjiri Ghate; Stan Tsing; Armando G. VillaseΓ±or; David Sha πŸ“‚ Article πŸ“… 2010 πŸ› Elsevier Science 🌐 English βš– 669 KB

JNK2 and p38a are closely related mitogen-activated protein kinases that regulate various cellular activities and are considered drug targets for inflammatory diseases. We have determined the X-ray crystal structure of the clinical phase II p38a inhibitor BIRB796 bound to its off-target JNK2. This s