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Inhibition of polyamine biosynthesis in Phytophthora infestans and Pythium ultimum

✍ Scribed by D. R. WALTERS; J. P. KEENAN; T. COWLEY; A. McPHERSON; N. D. HAVIS


Book ID
110856931
Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
408 KB
Volume
44
Category
Article
ISSN
0032-0862

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## Abstract We have earlier demonstrated that inhibition of polyamine biosynthesis with difluoromethylornithine (DFMO) can be used to enhance the cytotoxicity of herpes simplex virus thymidine kinase/ganciclovir (HSV‐TK/GCV) gene therapy in different tumor cell lines. Here, the utility of this trea