The polyamine biosynthesis inhibitor D,L-a-Difluoromethylornithine hydrochloride monohydrate (DFMO) has cytostatic and cytotoxic effects against various human tumor cell lines in vitro. We measured levels of the polyamines putrescine and spermidine in the urine of cancer patients undergoing "convent
✦ LIBER ✦
Inhibition of polyamine biosynthesis in Crithidia fasciculata by d,l-α-difluoromethylornithine and d,l-α-difluoromethylarginine
✍ Scribed by Karl J. Hunter; Carolyn A.M. Strobos; Alan H. Fairlamb
- Book ID
- 113260923
- Publisher
- Elsevier Science
- Year
- 1991
- Tongue
- English
- Weight
- 696 KB
- Volume
- 46
- Category
- Article
- ISSN
- 0166-6851
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We have examined the influence of cyclosporin A (CsA), administered together with the polyamine antimetabolite, o-difluoromethylornithine (DFMO), on growth of the Roser acute T-cell leukaemia in PVG rats and on growth of the EL4 lymphoma in C57BU6 mice. CsA or DFMO alone, administered from the time