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Inhibition of poly(ADP-ribose) polymerase (PARP) influences the mode of sulfur mustard (SM)-induced cell death in HaCaT cells

✍ Scribed by K. Kehe; K. Raithel; H. Kreppel; M. Jochum; F. Worek; H. Thiermann


Book ID
105870619
Publisher
Springer-Verlag
Year
2007
Tongue
English
Weight
490 KB
Volume
82
Category
Article
ISSN
0340-5761

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## Abstract Continuously generated hydrogen peroxide (H~2~O~2~) inhibits typical apoptosis and instead initiates a caspase‐independent, apoptosis‐inducing factor (AIF)‐mediated pyknotic cell death. This may be related to H~2~O~2~‐mediated DNA damage and subsequent ATP depletion, although the exact